Review
Ovarian cancer mouse models: a summary of current models and their limitations
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* Corresponding author: Sham S Kakar sskaka01@louisville.edu
Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
Journal of Ovarian Research 2009, 2:12 doi:10.1186/1757-2215-2-12
Published: 28 September 2009Abstract
Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease.