Table 2 |
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|
Summary of promoter and targeted genes of granulosa cell tumors (GCT). |
||||
|
Authors |
Promoter |
Targeted gene |
Tumorigenesis |
Limitation |
|
|
||||
|
Kananen et al. (1995) |
α-subunit of inhibin |
SV40 TAg |
Yes |
|
|
Nilson et al. (2000) |
α-subunit of inhibin |
LHβCTP |
Yes |
Females unable to reproduce |
|
Garson et al. (2003) |
OSP-1 |
SV40 TAg |
Yes |
developed tumors |
|
Boerboom et al. (2005) |
MISIIR/Cre |
mutant β-catenin |
Yes |
Transient expression |
|
Lague et al. (2008) |
MISIIR/Cre |
PTEN-/- & CTNNB1-/- |
Yes |
Transient expression |
|
|
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|
Fong and Kakar Journal of Ovarian Research 2009 2:12 doi:10.1186/1757-2215-2-12 |
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