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Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients

Michael F Gallagher1,2* email, Richard J Flavin4* email, Salah A Elbaruni1,2* email, Jamie K McInerney1,2 email, Paul C Smyth1 email, Yvonne M Salley1,2 email, Sebastian F Vencken1,2 email, Sharon A O'Toole3 email, Alexandros Laios3 email, Mathia YC Lee5 email, Karen Denning1 email, Jinghuan Li1 email, Sinead T Aherne1 email, Kai Q Lao6 email, Cara M Martin1,2 email, Orla M Sheils1 email and John J O'Leary1,2 email

1  Department of Histopathology, University of Dublin, Trinity College, Institute of Molecular Medicine, St James's Hospital, Dublin 8, Ireland

2  Department of Pathology, Coombe Women and Infants University Hospital, Dublin 8, Ireland

3  Department of Obstetrics and Gynaecology, University of Dublin, Trinity College, Institute of Molecular Medicine, St James's Hospital, Dublin 8, Ireland

4  The Centre for Molecular Oncologic Pathology, The Dana Faber Cancer Institute, Boston, MA02115, USA

5  NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore

6  Applied Biosystems, 850 Lincoln Centre Dr, Foster City, CA 94404, USA

author email corresponding author email* Contributed equally

Journal of Ovarian Research 2009, 2:19doi:10.1186/1757-2215-2-19

Published: 16 December 2009

Additional files

Additional file 1:

miRNAs in undifferentiated EC cells. miRNAs expressed in each undifferentiated cell type and their chromosomal clustering are listed. Additionally, the relative expression values of miRNAs in undifferentiated 2102Ep cells compared to undifferentiated NTera2 cells are detailed.

Format: PDF Size: 93KB Download file

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Open Data

Additional file 2:

Top ten miRNAs in undifferentiated 2102Ep EC cells compared to undifferentiated NTera2 cells and their associations with malignancy. The top ten miRNAs up- and down-expressed in undifferentiated 2102Ep cells compared to undifferentiated NTera2 cells, their previous associations with malignancy and these references are detailed.

Format: PDF Size: 104KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

miRNAs in differentiated EC cells: Group 1-4. miRNAs expressed in differentiated cells were divided into four groups based on their expression patterns. The miRNAs expressed in each group and their chromosomal clustering is detailed.

Format: PDF Size: 119KB Download file

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Open Data

Additional file 4:

The association of Group 3 and 4 miRNAs with malignancy. Group 3 and 4 miRNAs, their previous associations with malignancy and these references are detailed.

Format: PDF Size: 96KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Comparison of miRNAs in EC cells and OSC patient samples. miRNAs expressed in OSC samples, their rankings, chromosomal clustering and overlap with EC cells are described.

Format: PDF Size: 103KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data
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