Table 1 |
||||
|
Summary of ovarian cancer cell xenograft studies in nude mice. |
||||
|
429T |
429T-ALK3QD |
|||
|
|
|
|||
|
-Dox |
+Dox |
-Dox |
+Dox |
|
|
|
|
|
|
|
|
n a |
14 |
15 |
15 |
14 |
|
No. of mice with ascites (%) |
6 (42.9) |
7 (46.7) |
6 (40.0) |
4 (28.6) |
|
Mean ascites volume (± SEM) |
1.5 (± 0.9) |
1.0 (± 0.6) |
0.7 (± 0.4) |
1.1 (± 0.5) |
|
No. of mice with tumours (%) |
10 (71.4) |
9 (60.0) |
7 (46.7) |
6 (42.9) |
|
Mean tumour number (± SEM) |
7.5 (± 2.7) |
10.4 (± 3.6) |
6.2 (± 2.0) |
2.2 (± 1.3) |
|
Tumour sites (number of mice)b |
Pw (5) |
Pw (8) |
Pw (3) |
Pw (4) |
|
Spl (4) |
Int (1) |
Om (6) |
Lv (1) |
|
|
Spl (2) |
Int (1) |
Om (8) |
Lv (4) |
|
|
Spl (3) |
Int (2) |
Om (6) |
Lv (4) |
|
|
Spl (2) |
Int (0) |
Om (1) |
Lv (1) |
|
|
|
||||
|
a - Two mice died (not due to tumour growth; cause unknown) prior to the experimental endpoint resulting in 14 mice for the 429T -Dox group and 14 mice for the 429T-ALK3QD +Dox group. b - Number of macroscopic tumour nodules (≥1 mm diameter) was scored. Observed tumour sites (i.e. adherent tumour nodules on tissue/organ surface) were: peritoneal wall (Pw), spleen (Spl), intestine (Int), omentum (Om) and liver (Lv). |
||||
|
Shepherd et al. Journal of Ovarian Research 2010 3:5 doi:10.1186/1757-2215-3-5 |
||||
