Research
Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome
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* Corresponding author: Afshin Mohammadi Mohamadi_afshin@yahoo.com
1 Department of Radiology, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Endocrinology, Urmia University of Medical Sciences, Urmia, Iran
3 Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, Iran
4 Department of public health, Urmia University of Medical Sciences, Urmia, Iran
5 Student research committee, Urmia University of Medical Sciences, Urmia, Iran
Journal of Ovarian Research 2011, 4:19 doi:10.1186/1757-2215-4-19
Published: 24 October 2011Abstract
Background
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of childbearing age, and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current study was to evaluate early atherosclerotic findings in patients with PCOS.
Methods
We enrolled 46 women with PCOS and 45 normal control subjects who were referred to our hospital's endocrinology outpatient clinic. Carotid intima media thickness (CIMT) and flow-mediated dilatation (FMD) were performed in both cases and matched controls.
Results
Patients with PCOS showed an increased mean CIMT (0.63 ± 0.16 mm) when compared with the control subjects (0.33 ± 0.06 mm). This difference was statistically significant (p = 0.001). The mean FMD in young patients with PCOS was 10.07 ± 1.2%, while it was 6.5 ± 2.06% in normal subjects. This difference was also statistically significant (p = 0.001).
Conclusion
Our findings suggest that PCOS is related with early atherosclerotic findings.