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Open Access Case report

Lung cancer diagnosis on ovary mass: a case report

Nunzia Simona Losito1, Cono Scaffa2, Monica Cantile1*, Gerardo Botti1, Raffaele Costanzo12, Angela Manna1, Renato Franco1 and Stefano Greggi2

Author Affiliations

1 Department of Surgical Pathology, National Cancer Institute “G. Pascale”, Naples, Italy

2 Department of Gynecologic Oncology, National Cancer Institute “G. Pascale”, Naples, Italy

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Journal of Ovarian Research 2013, 6:34  doi:10.1186/1757-2215-6-34

Published: 10 May 2013


Metastatic neoplasms to the ovary often cause diagnostic problems, in particular those large ovarian masses mimicking primary tumors. Most of these tumors arise from digestive system or breast, while 37-year-old woman diagnosed as right adnexal complex mass, with a subpleural nodule in the apical part of the left lower lobe, at preoperative chest computed tomography scan. The patient underwent total abdominal hysterectomy with right salpingo-oophorectomy (ovarian mass 220 × 200 mm), total omentectomy, left ovarian biopsy, peritoneal random biopsies, and peritoneal washings for cytology. Pathologic and immunohistochemical examination of ovarian specimen suggested morphology and expression of metastatic lung adenocarcinoma with an intense positivity for Thyroid Transcriptional Factor-1 (TTF-1) and Cytokeratin 7 (CK7) staining. Fine needle biopsy of the lung nodule found epithelioid like malignant cells, confirming the diagnosis of an ovarian metastasis from a primary lung cancer.

This report focused on the clinical and pathologic diagnostic challenge of distinguishing secondary from primary ovarian neoplasms. Issues on useful immunohistochemical stains are also discussed.

Lung adenocarcinoma; Ovarian metastasis; Thyroid transcription factor 1